Areas of Interest:
Our lab focuses on the neural circuitry underlying learning and behavior. We are specifically interested in how motivation-, arousal-, and feeding-related circuits can modulate higher-order brain areas and their responses to salient, learned cues in the environment.
We use a combination of techniques and approaches to map neural circuits in mice, including neuroanatomy, behavior, optogenetics, and in vivo calcium imaging. The goal is to identify specific neuronal projections, record their activity during motivated behaviors & learning, and manipulate their activity to demonstrate a functional role in behavior. We are currently interested in how specific hunger and sleep promoting circuits in the hypothalamus can facilitate learning of, and appropriate responses to, motivationally relevant sensory cues.
Christian Burgess, Yoav Livneh, Rohan Ramesh, and Mark Andermann.
2018. Gating of visual processing by homeostatic need. Current Opinion in Neurobiology (49): 13-18.
Yoav Livneh, Rohan Ramesh,Christian Burgess, Kirsten Levandowski, Joseph Madara, Henning Fenselau, Glenn Goldey, Nick Jikomes, Jon Resch, Veronica Diaz, Bradford Lowell, and Mark Andermann.
2016. Dynamic GABAergic afferent modulation of AgRP neurons. Nature Neuroscience (19): 1628-1635.
Alastair Garfield*, Bhavik Shah*, *, Christian Burgess*, Monica Li*, Chia Li, Jennifer Steger, Joseph Madara, John Campbell, Daniel Kroeger, Thomas Scammell, Bakhos Tannous, Martin Myers Jr, Mark Andermann, Michael Krashes and Bradford Lowell.
2017. Homeostatic circuits selectively gate food cue responses in insular cortex. Nature (546): 611-616.
Christian Burgess*,Rohan Ramesh*, Arthur Sugden, Kirsten Levandowski, Margaret Minnig, Henning Fenselau, Bradford Lowell, and Mark Andermann.
2016. Hunger dependent enhancement of food cue responses in mouse postrhinal cortex and amygdala. Neuron (91): 1-16.
Yael Mandelblat-Cerf*, Rohan Ramesh*, Christian Burgess*, Paola Patella, Zongfang Yang, Bradford Lowell, Mark Andermann.
2015. Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales. eLife 4: e07122.
Christian Burgess and John Peever.
2013. A noradrenergic mechanism functions to couple motor behavior with arousal state. Current Biology 23(18): 1719–1725.
Christian Burgess, Yo Oishi, Takatoshi Mochizuki, John Peever, and Thomas Scammell.
2013. Amygdala lesions reduce cataplexy in orexin knock-out mice. J Neuroscience 33(23): 9734-9742.
View publications on PubMed - NCBI