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    By Alpha|By Interest|Emeritus

John F Greden M.D.
Research Professor, MBNI
Rachel Upjohn Professor of Psychiatry and Clinical Neurosciences
Exec. Director, Univ. of Michigan Depression Center

1313 Rachel Upjohn Building, 4250 Plymouth Road
Ann Arbor, MI 48109-5763


(734) 763-9629


Current Research Interests:

  • Relationship of neuroendocrine dysregulation to mood disorders
  • Recurrent depression and extended maintenance treatment and medications
  • Short- and long-term effects of different sequences of medication and/or psychotherapy for the treatment of unipolar depressions resistant
  • Longitudinal course of Major Depressive Disorder (MDD)

My primary research theme of late has been the long-term course and treatment of major depressive disorder. Recent book chapters, papers, and presentations have focused upon various facets of this issue, including refinement of a treatment algorithm for clinicians and comprehensive guidelines for management of side effects. Clinical assessment of recurrent depression and the accompanying neuroendocrine parameters in psychiatric patients are used to classify, monitor, predict treatment response and understand the pathophysiology of patients with various diagnostic subtypes. Extended maintenance treatment is of particular interest, and data continue to be generated which support the efficacy of pharmacotherapy beyond the acute stage. Other research areas include continued involvement with the University of Michigan's NIAAA-funded Alcohol Research Center and the School of Social Work's Poverty, Risk and Mental Health NIMH-funded grant.

Selected Publications:

Brower, K.J., Aldrich, M.S., Robinson, E.A., Zucker, R.A., Greden, J.F.: Insomnia, self-medication, and relapse to alcoholism. American Journal of Psychiatry. 158:399-404, 2001

Marcus, S.M., Barry, K.L., Flynn, H.A., Tandon, R., Greden, J.F.: Treatment guidelines for depression in pregnancy. [Review] [21 refs] International Journal of Gynaecology & Obstetrics. 72:61-70, 2001

Ghaziuddin, N., King, C.A., Welch, K.B., Zaccagnini, J., Weidmer-Mikhail, E., Mellow, A.M., Ghaziuddin, M., Greden, J.F.: Serotonin dysregulation in adolescents with major depression: hormone response to meta-chlorophenylpiperazine (mCPP) infusion. Psychiatry Research. 95:183-94, 2000

Greden, J.F., Lopez, J.: Treatment of Major Depressive Disorder. In: Current Psychiatric Therapy II. Edited by D. L. Dunner. W. B. Saunders, Philadelphia, pp. 221-232, 1997


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